Duloxetine HCl (Cymbalta) for the Treatment of Depression, Neuropathic Pain, Fibromyalgia, and Stress Urinary Incontinence
نویسندگان
چکیده
84 P&T® • February 2006 • Vol. 31 No. 2 INTRODUCTION Serotonin (5-HT) and norepinephrine (NE) are neurotransmitters thought to help regulate human emotions and sensitivity to pain. When these neurotransmitters are not in balance, people may become depressed and may be more likely to experience painful physical symptoms.1 The combination of emotional and painful physical effects of depression can have a tremendous negative impact on a person’s quality of life.2
منابع مشابه
Duloxetine for painful diabetic neuropathy and fibromyalgia pain: systematic review of randomised trials
BACKGROUND Duloxetine hydrochloride is a reuptake inhibitor of 5-hydroxytryptamine and norepinephrine used to treat depression, generalized anxiety disorder, neuropathic pain, and stress incontinence in women. We investigated the efficacy of duloxetine in painful diabetic neuropathy and fibromyalgia to allow comparison with other antidepressants. METHODS We searched PubMed, EMBASE (via Ovid),...
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Duloxetine (DLX), is a selective serotonin-norepinephrine reuptake inhibitor (SNRI) recommended for maintenance treatment of major depressive disorder, neuropathic pain especially diabetic polyneuropathy (first-line treatment), generalized anxiety disorder, stress urinary incontinence and fibromyalgia. The present investigation describes the validation of rapid, sensitive, cost effective and re...
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Objective: Saffron was found efficient and safe in treatment of neuropsychiatric disorders, in particular depression. We compared the efficacy of saffron with duloxetine in treatment of patients with fibromyalgia. Materials and Methods: In this double-blind parallel-group clinical trial, outpatients with fibromyalgia were randomized to receive either saffron 15 mg or duloxetine 30 mg starting w...
متن کاملPHARMACOEPIDEMIOLOGYAND PRESCRIPTION Intensive monitoring of duloxetine: results of a web-based intensive monitoring study
Purpose Duloxetine (Cymbalta) is a serotonin (5-HT) and norepinephrine (NE) re-uptake inhibitor indicated for the treatment of depression, diabetic peripheral neuropathic pain and general anxiety disorder. The aim of this study is to gain insight in the user and safety profile of duloxetine in daily practice, reported by patients via a web-based intensive monitoring system during their first 6 ...
متن کاملManagement of depression in the presence of pain symptoms.
Somatic illness is frequently associated with depression and anxiety and major depression significantly increases risk of severe medical conditions, e.g. cardiovascular illness. One of the most frequent comorbidities is that of depression and pain. Alterations in noradrenergic and serotonergic neurotransmissions in the central nervous system have been implicated in the joint pathophysiology of ...
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